In Vitro Labeling of RNA in Isolated Nucleoli of the Walker Tumor and Liver* TAB SUK Ro AND HARRIS BUSCH

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ethanol was also required for the optimal activity. The pH optimum was 8.2 for both tumor and liver nucleoli. Maximum incorporation of isotope into RNA was found at 15-30 minutes after the incubation was begun. The reactions were DNA-dependent, as shown by sensitivity to actinomycin D. Evidence for internucleotide incorporation of ATP-P32 was obtained by analysis of P32distribution into nucleotide monophos-

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تاریخ انتشار 2006